ABSTRACT
T.H Lanman and T.H Ingalls showed that guinea pigs maintained on one fifth of the minimal protective dose of ascorbic acid showed wound healing which was inferior to that of controls receiving a full diet. A.N Hunt summarized the essentials of wound healing as migration and proliferation of epidermal and mesodermal cells, production of an intercellular matrix, and the formation of new blood vessels. He also studied the effect of scurvy on healed wounds and found that the new collagen of the scar reverted to an argyrophil precollagenous state. K.A.L Aschoff and W. Koch are credited with being the first to observe the defects of intercellular connective tissues in scurvy. They carried out post-mortem studies on soldiers who had died of scurvy during World War I and demonstrated constant pathological changes in all the supporting tissues of the body. M. Taffel and S.C Harvey reported weakness in the healing of stomach wounds in partially scorbutic guinea pigs.
