After reading this chapter, you should be able to:

sketch the myogenic response of arterioles to a pressure change and explain its importance (13.2);

list the chief roles of nitric oxide in the circulation (13.3);

state the role of metabolic hyperaemia and name the putative mediators (13.4);

give thumbnail sketches of the autacoids histamine, bradykinin, serotonin, platelet-activating factor, prostacyclin and thromboxane (13.5);

illustrate ‘autoregulation’ by drawing a plot of blood flow versus perfusion pressure, and draw a second curve to show how autoregulation is affected by metabolic hyperaemia (13.6);

explain how dilatation is co-ordinated along the arterial tree during exercise (13.7);

outline how post-ischaemic hyperaemia arises (13.8);

explain the basis of ischaemia-reperfusion injury (13.9).