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      Chapter

      The cardiac myocyte: excitation and contraction
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      Chapter

      The cardiac myocyte: excitation and contraction

      DOI link for The cardiac myocyte: excitation and contraction

      The cardiac myocyte: excitation and contraction book

      The cardiac myocyte: excitation and contraction

      DOI link for The cardiac myocyte: excitation and contraction

      The cardiac myocyte: excitation and contraction book

      ByNeil Herring, David J. Paterson
      BookLevick's Introduction to Cardiovascular Physiology

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      Edition 6th Edition
      First Published 2018
      Imprint CRC Press
      Pages 20
      eBook ISBN 9781351107754
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      ABSTRACT

      After reading this chapter you should be able to:

      outline the ultrastructure and functions of the sarcomere, sarcoplasmic reticulum (SR), transverse tubules and gap junctions (3.2);

      explain how the interactions between calcium (Ca2+), actin and myosin produce contraction (3.3);

      sketch a ventricular action potential, label the various phases and name the ion channels responsible for each (3.6; 3.7);

      explain the link between the action potential plateau and contractility (3.9);

      describe Ca2+ cycling in cardiac myocytes and the factors affecting Ca2+ store size (3.9);

      state the effect of diastolic length on contractile force (3.9; 3.10);

      outline the effect of the following agents on contractile force: catecholamines; Ca2+ channel blockers; phosphodiesterase inhibitors; digoxin (3.8; 3.9);

      draw and explain a delayed afterdepolarization (3.11).

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