ABSTRACT
Because all aspects of nervous system function rely on synaptic communication, it is crucial that axons and dendrites make connections with the appropriate target cells. For this neural connectivity, or wiring, to be established, the extending nerve fibers must first be guided to the correct target tissue, where they will begin to seek an appropriate partner cell. Once the nerve fibers contact the proper target cell, they then begin to differentiate the cellular machinery needed to form a presynaptic nerve terminal and develop a mature synaptic connection.
