ABSTRACT
Many technical improvements in MR scanner hardware and software have made these perfusion weighted imaging techniques more accurate and robust and have enabled their implementation in research applications and clinical routines. However, there remain a number of limitations and issues that must be taken into account whenever acquiring and interpreting perfusion methods since there are several assumptions and model fits involved, which can be prone to artifacts and pitfalls. The chapter introduces and analyzes the limitations and pitfalls in a qualitative way, as well as to evaluate possible mitigating strategies or solutions to overcome them. It seems that in the future, the use of protocols that combine exogenous contrast methods with the endogenous contrast in ASL will have a great impact in the clinical routine.
