ABSTRACT
Seven-membered heterocyclic compounds are important structural moieties found in a number of medicinal compounds. Many methods have been developed for the construction of nitrogen (N)-containing heterocyclic compounds, most of them led to five- and six-membered ring systems, while the synthesis of seven-membered and larger heterocyclic compounds is quite limited. L. Wu and co-workers synthesized seven-membered heterocyclic compounds regioselectively by a Bronsted base-modulated intramolecular oxidative amination in the presence of palladium (Pd) catalyst. H. Alper et al. reported many multi-component reactions based on a Pd-catalyzed carbonylation reaction for the preparation of N-heterocyclic compounds. Good yield of heterocyclic products was obtained by coupling of N-allyl-2-aminobenzylamine derivatives with aryl bromides in the presence of Pd catalyst. A number of six-, seven-, and eight-membered nitrogen- and oxygen-heterocycles were synthesized regioselectively under very mild conditions in good yields. The valuable heterocyclic or carbocyclic scaffolds were synthesized via an intramolecular coupling between allyl and aryl halide moieties in the presence of Pd catalyst.
