ABSTRACT
Introduction ........................................................................................................ 387
Collagen............................................................................................................... 388
Collagen Hydration ........................................................................................... 388
Collagen and the Polyproline II Conformation ............................................ 390
PPII in Globular Proteins and Host-Guest Experiments ........................... 392
Protein Unfolding and the PPII Conformation............................................. 393
Protein Folding................................................................................................... 395
Conclusions......................................................................................................... 396
Acknowledgments ............................................................................................. 397
References ........................................................................................................... 397
During the past 10 years, tremendous advances have occurred in protein
science that are due, in large part, to combining experimental studies with
sophisticated computer simulations. In particular, these techniques have
revealed the critical role that water plays in the function and structural
stability of proteins, an aspect largely ignored in the past (Ghosh et al., 2003).
