Biologically Based Lung Dosimetry and Exposure–Dose– Response Models for Poorly Soluble Inhaled Particles*

Acknowledgment ......................................................................................................................... 383

References .................................................................................................................................... 383

Inhaled airborne particles may be deposited in the respiratory tract with a probability that depends

on the physical properties of the particles, the velocity of the air, and the structure of the airways.

Once deposited, particles may be retained at the site of deposition, translocated elsewhere in the

body, or cleared by the biological processes specific to each region of the respiratory tract.