ABSTRACT
An examination of the analytical sample: resin support 2.1 Introduction Before the synthesis of a combinatorial library, the sequence of reactions to be used needs to be validated and optimized to give the highest yield and fewest byproducts. Unlike synthesis in solution phase or on soluble polymers, solid-phase synthesis requires a major effort in reaction validation and optimization. One of the major obstacles for adapting reactions to solid support is the lack of knowledge about the solid support and the effects of the support on organic reactions. The consequences of using suboptimal conditions are poor reaction yields, the formation of side products, and even failed syntheses. This chapter examines properties of solid-phase samples and some analytical studies targeted to understand these properties. It will also examine resin swelling and the effects of swollen resin on solid-phase organic reactions. These solid supports are an important platform on which to build combinatorial libraries as well as analytical samples to be analyzed during the reaction optimization process. The success of many analytical methods relies on the physicochemical and swelling properties of solid supports.
