ABSTRACT
The rapid progress in the human genome project has stimulated the development of diverse analytical
methods for mutation detection, elucidation of complex biological problems, molecular diagnosis and
prognosis of disease, and assessment of treatment. The coupling of a nucleic acid recognition layer with
the electrochemical transducer and the use of the sensor for the detection of sequences specific to various
pathogens or for monitoring pollutants interacting with the recognition layer have been the object of
several research works [1]. The electrochemical sensors for DNA sequencing may show a growing role in
various fields, where an accurate, low cost, and fast-measuring system is required. The improvement of
the existing systems and the design of new conceptual systems require a continuous upgrading of all the
components of the electrochemical DNA detection systems.
