ABSTRACT
PL-OOH ...........................................................................................194 9.4.7 Physiological Significance of the GPx Activity of GSTs ...............195
9.5 Nonenzymatic Physiological Roles of GSTs...............................................197 Acknowledgment ...................................................................................................198 References..............................................................................................................198
Glutathione S-transferases (GSTs) are primarily viewed as the enzymes involved in detoxification of xenobiotics, but in recent years compelling evidence has emerged that strongly suggests that these enzymes are also responsible for important physiologic functions. GSTs are multifunctional and besides catalyzing the conjugation of electrophiles to glutathione (GSH), these enzymes also display isomerase and glutathione peroxidase (GPx) activities. Isomerase activity of GSTs catalyzing the
