ABSTRACT
Proliferation......................................................................................215 10.5.2 Inhibition of Differentiation and Apoptosis ....................................217 10.5.3 Inhibition of the Activation of JNK and Caspases..........................218 10.5.4 Accelerated Metabolism of 4-HNE by GSTs Protects against
Stress-Induced Apoptosis ................................................................219 10.5.5 Inhibition of GS-HNE Efflux Potentiates Stress-Induced
Apoptosis..........................................................................................219 10.5.6 Depletion of 4-HNE by GSTs Leads to Transformation and
Immortalization of Some Adherent Cells........................................221 10.5.7 Overexpression of hGSTA4-4 Affects Expression of a
Multitude of Genes in HLE B-3 Cells ............................................222 10.5.8 GSTs Can Modulate Signaling by Interacting with
SAPK/JNK .......................................................................................222 10.6 Future Directions..........................................................................................224 Acknowledgment ...................................................................................................227 References..............................................................................................................227
The role of glutathione S-transferases (GSTs) in protecting cells from lipid peroxidation was discussed in the preceding chapter. In recent years, the physiological significance of this function of GSTs has begun to unfold, suggesting not only their importance as antioxidant enzymes but also their role in the regulation of stressmediated signaling. Recent studies indicate that the
