ABSTRACT
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Electroporation can be defined as an electrical enhancement strategy whereby relatively high
voltages are applied to the skin for very brief periods in order to create temporarily aqueous
pores within the membrane. These apertures provide pathways for molecular penetration
through the skin. Its potential for increasing the transdermal delivery of molecules was first
demonstrated in the 1990s [1] and since then the technique has been combined with other
enhancement strategies to examine if penetration of dermally absorbed drugs can be further
increased, e.g., estradiol [2] or to broaden the range of candidate drugs, which may be
delivered by this route, e.g., insulin [3]. This chapter will examine a number of recent reports,
which combined electroporation and chemical penetration enhancement strategies, with a
particular emphasis on the use of lipids and lipid vesicles as suitable chemical adjuvants.
