ABSTRACT
The median age at diagnosis is approximately 65 years, and there is a slight male predominance. Weakness, fatigue, oronasal bleeding, weight loss, and visual or neurologic disturbances are the most common presenting symptoms. Bone pain is rare. Fever, night sweats, and weight loss may be seen. Pallor, hepatosplenomegaly, and peripheral lymphadenopathy are the most frequent physical findings. Retinal lesions, including hemorrhages, exudates, and venous congestion with vascular segmentation (“sausage” formation) may be impressive. Peripheral neuropathy may occur.
