ABSTRACT
Upon activation of mitogenic signaling cascades, cells commit to entry into a series of regulated steps allowing traverse of the cell cycle. Synthesis of DNA (genome duplication), also known as S phase, is followed by separation into two daughter cells (chromatid separation) or M phase. During the G
phase (the time between the S and M phases), cells can repair errors that occur during DNA duplication, preventing the propagation of these errors to daughter cells. In contrast, the G
phase (the time between the M and S phases) represents the period of commitment to cell
cell cycle checkpoints
are elicited.
