ABSTRACT

Mechanisms of Action .....................................................................207 9.7 Pharmacology of (

R

)-Roscovitine ...............................................................209 9.7.1 Quantification of (

R

)-Roscovitine....................................................209 9.7.2 Pharmacokinetics .............................................................................209 9.7.3 Metabolites .......................................................................................210

9.8 Anti-Tumor Effects of (