Mouse Models to Study the In Vivo Fuction of Cyclin-Dependent Kinases in Normal Homeostasis and Tumor Development

CDKs and the Control of Cell Proliferation ............................................56 3.3 Loss-of-Function Mouse Models of G

Cyclins and CDKs .........................59 3.3.1 Mice Lacking D-Type Cyclins: How Many Are Too Few?..............59 3.3.2 Mice Lacking CDK4 and CDK6: Fetal Hematopoietic Failure .......65 3.3.3 Mice Lacking E-Cyclins: Endoreplication Defects...........................67 3.3.4 Mice Lacking CDK2: CDK2 Essential No More .............................68

3.4 CDKs and Tumor Development ....................................................................70 3.4.1 Alteration of G