ABSTRACT

Orally administered drugs are absorbed from the gastrointestinal tract through a number of distinct mechanisms. At the same time, nutrients are absorbed through similar mechanisms. At times, this leads to a competition that alters the adsorption of either the drug or the specific nutrient, or both. A drug-nutrient interaction is defined as an alteration of the pharmacokinetics or pharmacodynamics of drug absorption, or of a nutritional element, or a compromise in nutritional status as a result of the addition of a drug.1