The X-Ray Structure of Human Acid-β-Glucosidase: Implications for Second-Generation Enzyme Replacement Therapy

Introduction..............................................................................................................85 The Three-Dimensional Structure of GlcCerase.....................................................86 A Lid at the Entrance to the Active Site of GlcCerase ..........................................87 Mutations in GlcCerase Leading to Gaucher Disease............................................89 Conclusions and Future Perspectives ......................................................................93 References................................................................................................................94