ABSTRACT
The safety assessment of bovine somatotropin (bST) differs in some respects from safety assessments for other proteins used in food production. Since bST is a veterinary production drug that increases the efficiency of milk production, one has to
7.1 Introduction .................................................................................................. 167 7.2 Discovery of bST and Its Commercial Development for Use
in Dairy Cows ............................................................................................... 168 7.3 Food Safety Assessment for Use of bST in Dairy Cows .............................. 172
7.3.1 Species-Limited Activity of Somatotropins in Humans ................... 175 7.3.2 Digestibility of bST and Lack of Oral Bioavailability ...................... 177 7.3.3 Rat Safety Studies ............................................................................. 178 7.3.4 Residues of Sometribove in Meat and Milk of Dairy Cattle ............ 180 7.3.5 IGF-1 Safety Assessment .................................................................. 181 7.3.6 Regulatory Assessment of the Impact of bST on Milk
and Meat IGF-1 Levels ..................................................................... 182 7.3.7 Assessment of Potential Oral Activity of IGF-1 ............................... 183 7.3.8 Concentrations of IGF-1 in Milk ....................................................... 184 7.3.9 Dietary Risk Assessment for IGF-1 in Milk ..................................... 185 7.3.10 Mitogenic Activity of IGF-1 .............................................................. 187
7.4 Meat and Milk Composition ......................................................................... 189 7.5 Mastitis and Antibiotics ................................................................................ 193 7.6 Milk Labeling ............................................................................................... 193 7.7 Conclusions ................................................................................................... 194 References .............................................................................................................. 194 Appendix 1 .............................................................................................................202 Appendix 2 .............................................................................................................208
