ABSTRACT

AR of T Cells ............................................262 16.4 Meningitis ...................................................................................................263 16.5 Peritonitis ....................................................................................................265 16.6 Septic Arthritis ............................................................................................267 16.7 Sepsis ..........................................................................................................270 16.8 Conclusion ..................................................................................................280 References..............................................................................................................280

Adenosine, through its receptors, is an important mediator of inflammation reduction. In this chapter, we will discuss the role of the innate immune response to infection and its relationship to inflammation, which can often be deleterious to the host. The chapter will first describe the cellular response to adenosine and adenosine receptor agonists before discussing the role of adenosine and its analogs in the treatment of meningitis, peritonitis, septic arthritis, and sepsis.