ABSTRACT
Adenosine Receptors ........................................301 18.2.2 Direct Antitumor Effects Induced by A
AR Agonists and Mechanisms Involved .............................................................302 18.2.2.1 Antitumor Effect of A
AR Agonists at
µM
Concentrations....................................................302 18.2.2.2 Antitumor Effect of A
AR Agonists at n
M
Concentrations....................................................303 18.2.2.3
In vivo
Effect of A
AR Agonists ..................................305 18.2.2.4 A
AR Fate upon Chronic Activation............................305 18.2.3 Indirect Antitumor Effects Mediated via
Adenosine and its Receptors .........................................................307 18.3 Enhancement of Chemotherapeutic and Chemoprotective Effects
via Adenosine Receptor Activation ............................................................308 18.3.1 A
AR Agonists and Antagonists and Chemotherapeutic Index Enhancement.........................................308
