ABSTRACT
TRP Definitions and Families ...............................................................................322 TRP Translocation as an Activation and Regulatory Mechanism........................324
Activation of SOC Channels by Protein Translocation to the Plasma Membrane...........................................................................324 Functional Modulation of TRPL and TRP3 Channels .............................325 Agonist-Induced Translocation of TRPC Channels..................................325 Modulation of TRPV Channel Activity ....................................................326
Concluding Remarks .............................................................................................327 Acknowledgments..................................................................................................328 References..............................................................................................................329
Cellular function, in particular neuronal activity, is the result of an orchestrated interplay between membrane receptors at the cell surface and intracellular signaling proteins. Membrane receptors transduce external signals into cellular responses by activating cytosolic metabolic pathways. Regulation of the spatial and temporal distribution of membrane receptors begins to be recognized as an important mechanism for controlling the magnitude and time course of cellular signaling.
