ABSTRACT
Acknowledgments ............................................................................................ 434
References ........................................................................................................ 434
At present, the use of peptide-and oligonucleotide-based macromolecules, both for
target validation and as biopharmaceutics, is limited by the availability of techniques
for both tissue and intracellular delivery. However, a number of recent
investigations have suggested that this problem can be overcome through the use
of cell-penetrating peptides (CPPs), in particular those derived from the TAT and
Antennapedia homeodomain.1 To date, the majority of these reports has been
concerned with CPP-mediated delivery of therapeutic peptides and protein in vivo,
which will be reviewed in the first section. In contrast, few studies have examined
their utility for the delivery of oligonucleotides such as antisense and short
interfering RNA (siRNA), which will be briefly discussed in Section 24.3.
