Tat-Derived Cell-Penetrating Peptides: Discovery, Mechanism of Cell Uptake, and Applications to the Delivery of Oligonucleotides

Acknowledgments .............................................................................................. 38

References .......................................................................................................... 39

Peptide and nucleic acid-based drugs offer a large array of strategies to regulate very

specifically gene expression or to rescue deficient gene expression. A major

limitation is, however, the poor efficiency with which these large hydrophilic

biomolecules cross biological barriers.