ABSTRACT

Alzheimer’s disease

,

Parkinson’s disease

, and

amyotrophic lateral sclerosis

, and in pathological conditions such as ischemia and excitotoxicity. The importance of preventing oxidative-stress-induced neuronal damage has recently been emphasized. Because of its powerful antioxidant activity, saffron extract, crocetin, or crocin could be useful in the therapy of brain neurodegenerative disorders, although their effects have not yet been evaluated.