Application of Chronic Extracellular Recording Method to Studies of Cocaine Self- Administration: Method and Progress

Nonpharmacological Effects and Testing Addiction Hypotheses .................. 37 2.4.1 Methods for Differentiating between Pharmacological and

Nonpharmacological Effects on Neural Activity ............................... 37 2.4.1.1 Acute Drug Effects .............................................................. 37 2.4.1.2 Chronic Drug Effects ........................................................... 38

2.4.2 Testing Drug Addiction Hypotheses ................................................... 39 2.5 Firing Patterns during Cocaine Taking .......................................................... 42

2.5.1 Overview of the Section ..................................................................... 42 2.5.2 Short-Duration Changes in Firing Time-Locked to the

Reinforced Lever Press ....................................................................... 42

2.5.2.1 Description of the Firing Patterns ....................................... 42 2.5.2.2 Determinants of the Firing Patterns ....................................44