ABSTRACT
From Hans Selye to Biochemical Coding of Stress Response................................. 75 CRF Signaling Pathways: Ligands and Receptors ...................................................77
CRF Ligands .................................................................................................77 CRF Receptors: Cloning and Pharmacological Characteristics .............................. 78 CRF Receptor Antagonists ...................................................................................... 79 Brain CRF1 Receptors and Stress-Induced Stimulation of Colonic Motor
Function ........................................................................................................80 Brain CRF1 Receptors and Stress-Related Hypersensitivity .................................. 81 CRF1 Receptors and Pathophysiology of IBS Symptoms ........................................ 82 Conclusions .............................................................................................................. 83 Acknowledgments ....................................................................................................84 References ................................................................................................................84
secretion involves “neural control via the hypothalamus and the hypophyseal portal vessels of the pituitary stalk.”3,4
