This chapter consists of two parts. First, the different levels of food interaction with drug pharmacokinetics are listed and broadly characterized, mainly by referring to existing review articles. Second, two examples of recent interesting new and somewhat unexpected interactions are described. These are the acute inhibition of hepatic oxidative drug conversion by a protein-rich meal and the enhancement of the CYP3A4-related intestinal hydroxylation of quinidine by a chronic high-salt diet.