ABSTRACT
CASRN: 86-88-4; DOT: 1651; molecular formula: C11H10N2S; FW: 202.27; RTECS: YT9275000; Merck Index: 12, 764 Physical state, color, and odor: Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste. Melting point (°C): 193-197 (Acros Organics, 2002) Boiling point (°C): Decomposes (NIOSH, 1994) Density (g/cm3): 1.895 using method of Lyman et al. (1982) Diffusivity in water (x 10-5 cm2/sec): 0.56 at 20 °C using method of Hayduk and Laudie (1974) Flash point (°C): Not applicable because ANTU is noncombustible (NIOSH, 1997) Lower explosive limit (%): Not applicable (NIOSH, 1997) Upper explosive limit (%): Not applicable (NIOSH, 1997) Octanol/water partition coefficient, log Kow: 1.65 at pH 6.5, 1.52 at pH 12 (shake flask-HPLC, Govers et al., 1986) Solubility in organics: 4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983) Solubility in water: 600 mg/L at 20 °C (quoted, Windholz et al., 1983) Environmental fate: Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25 °C was determined to be 8 x 10-5/h, resulting in a half-life of 361 d (Ellington et al., 1988). At 85 °C, hydrolysis half-
(Ellington et al., 1987). Emits toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Lewis, 1990). Exposure limits (mg/m3): NIOSH REL: TWA 0.3, IDLH 100; OSHA PEL: TWA 0.3; ACGIH TLV: TWA 0.3 mg/m3 (adopted). Symptoms of exposure: Vomiting, dyspnea, cyanosis, course pulmonary rales after ingestion of large doses (NIOSH, 1997) Toxicity: Acute oral LD50 for Norwegian rats 6-8 mg/kg (Cremlyn, 1991; Hartley and Kidd, 1987). Use: Rat poison. Banned in Britain due to carcinogenic impurities such as β-naphthylamine (Cremlyn, 1991).
