ABSTRACT
Proteome analysis of a particular cell or organ, or of body fluids such as plasma, urine, and others, makes it possible to identify biomarkers that respond to alterations in diet or any other treatment, and that may have a predictive value for the assessment of a human’s health status. To date, proteomics has not been applied on a large scale in human studies related to nutrition, yet it has obvious advantages over transcriptome profiling techniques in that it directly assesses the molecular entities that carry out the biological functions. This chapter summarizes the different approaches in proteomics research and provides some examples that demonstrate the state of the art of biomarker discovery based on proteome analysis and their implications for the development of personalized nutrition approaches.
