ABSTRACT
In this chapter we review the consequences of traumatic injury to the brain and spinal cord and the regenerative strategies that are being pursued to overcome the tissue degeneration that ensues. The chapter begins with a discussion of the epidemiology and pathogenesis of traumatic injury and is followed by a discussion of the challenges associated with promoting regeneration and limiting degeneration. Strategies for treatment are described including drug delivery, cell-based, and tis-
8.1 Introduction ................................................................................................ 221 8.1.1 Traumatic Injury in the Central Nervous System (CNS): Brain
and Spinal Cord ..............................................................................222 8.2 Environment of the Injured CNS: Challenges and Opportunities .............223
