ABSTRACT
Introduction............................................................................................................160 The
cp
Gene and Strains .......................................................................................161 Koletsky and SHROB................................................................................161 Congenic Strains........................................................................................161 Rat Mutations ............................................................................................161 JCR:LA-
cp
Strain ......................................................................................162 SHHF/Mcc Strain ......................................................................................162 LA/N-
cp
and SHR/N-
cp
Strains................................................................162 WKY/N-
cp
Strain ......................................................................................163 Pathophysiology of the JCR:LA-
cp
Rat ...............................................................163 Genotype, Hyperphagia, Body Weight, and Phenotype ...........................163 Leptin Status ..............................................................................................163 Insulin Resistance and Hyperlipidemia.....................................................164
Macrovascular Disease ..........................................................................................165 Atherosclerosis...........................................................................................165 Vasculopathy ..............................................................................................167 Sexual Dimorphism of Disease .................................................................169
Microvascular Disease...........................................................................................169 Glomerular Sclerosis .................................................................................169 Polycystic Ovary Disease ..........................................................................169 Impaired Wound Healing...........................................................................170 Dietary Effects ...........................................................................................172 Environmental Effects ...............................................................................173
Responses to Pharmaceuticals and Other Interventions .......................................173 Comparisons with Other Obese Rat Strains .............................................174
Maintenance of the Strain .....................................................................................175 Experimental Techniques ......................................................................................175
