ABSTRACT
The skin is the largest organ in the human body and has long been used as a site for administration of therapeutic agents for localized pharmacological actions (Kastrip and Boyd, 1983). Drug delivery through the skin for systemic effects, though limited, is a well-established branch of pharmaceutics. The stratum corneum, the outermost layer of the skin offers ex - cellent barrier properties to applied substances thus limiting the number of drug candidates for passive transdermal delivery to usually small, potent, and lipophilic compounds. Physical and chemical techniques have been used to improve the permeability of the skin to applied substances. Dermal iontophoresis is one of such physical techniques.
