ABSTRACT
The combination of real-time breath analysis and PBPK modeling provides an opportunity to effectively follow the changing kinetics of uptake, distribution, and elimination phases of a compound throughout a dermal exposure. The sensitivity of the ASGDI-MS/MS system for exhaled-breath analysis is pivotal in enabling studies wherein human volunteers are exposed to low levels of compounds for short periods of time. This real-time, in vivo method is suitable for studying the percutaneous absorption of volatile chemicals, and allows exposures to be conducted under a variety of exposure conditions, including occluded versus nonoccluded, rat versus monkey versus human, and soil versus water matrices (Thrall et al., 2000).
