ABSTRACT
Percutaneous absorption is a primary focal point for dermatotoxicology and dermatopharmacology. Local and systemic toxicity depend on a chemical penetrating the skin. The skin is both a barrier to absorption and a primary route to the systemic circulation. The skin’s barrier properties are impressive. Fluids and precious chemicals are reasonably retained within the body; at the same time hundreds of foreign chemicals are restricted from entering the systemic circulation. Even with these impressive barrier properties, the skin is a primary body organ that contacts the environment and is a route by which many chemicals enter the body. Some chemicals applied to the skin have proved to be toxic. These include pesticides, which in actuality are designed poisons.
