ABSTRACT
Among the dermatotoxicologic community working on immune skin effects manifested as allergic contact dermatitis, the proven effective strategy has been to develop and apply animal assays for identifi cation of chemical xenobiotics with allergenic potential and to assess the sensitization hazard potential of these environmental contactants for
human beings. Since 1935 (Landsteiner and Jacobs, 1935), the guinea pig has represented the reference animal model.
