ABSTRACT
Appropriate extrapolation from the harsh sensitization conditions of prospective testing to the real world of allergen exposure requires experience and much common sense.
The prospective testing of substances for their allergenicity in experimental animals can be done successfully without immunoadjuvants. The guinea pig nonadjuvant testing methods such as those of Driaze (a modifi cation of Landsteiner’s technique) or of Buehler rely on multiple injections or applications of the test material to the sensitization site to enhance the acquisition of DTH to the allergen (Landsteiner and Jacobs, 1935; Driaze et al., 1944; Draize, 1959; Buehler, 1965; Buehler and Griffi th, 1975).
