ABSTRACT
The choice of provocation protocols depends on the type of reaction involved. Although much work has been directed toward classifying drug eruptions and elucidating their mechanisms, they are still not well understood. Many of them are presumably mediated by immunological mechanisms, but there are also nonimmunological drug eruptions, idiosyncrasies, in genetically predisposed persons. In cases of nonimmunological drug eruptions, skin tests are usually negative, and systemic provocations are also often negative (Tables 67.2 and 67.3). Immunological drug eruptions may be classified into the four reaction types according to Coombs and Gell (Bruynzeel and Ketal, 1989).
