ABSTRACT
Exposure of cells to stress activates multiple intracellular signaling or signal transduction pathways along which signals move from the outside of the cell to the inside and between different intracellular locations. The result is an alteration in cellular activity and changes in the program of genes expressed in the responding cells. Ionizing radiation is one of the stresses that can initiate intracellular signaling and the response to that signaling can in turn modulate radiation response. In this chapter, the key players in the signal transduction process are briefly described and the dual effects of radiation-induced signaling and signal-mediated modulation of radiation response are discussed. Much of the material in this chapter is based on reviews by Schmidt-
Ullrich et al. [1], Dent et al. [2], and the references listed therein.
