ABSTRACT
Adipose Tissue ..........................................................................................500
22.4 Role of Leptin, the Product of Ob Gene, in Angiogenesis ......................501
22.5 Anti-Angiogenic Therapeutic Strategies to Regulate Obesity ..................501
22.6 Anti-Angiogenic Nutrients ........................................................................504
22.7 Conclusions ................................................................................................504
References ............................................................................................................505
Obesity, a worldwide epidemic, is associated with an increased risk for diverse
cardiovascular diseases including atherosclerosis, thrombosis, hypertension, hyper-
insulinemia, insulin resistance, type 2 diabetes, and cancer. Obesity is characterized
by an excess of fat mass caused by adipocyte hypertrophy and hyperplasia.
Angiogenesis, the formation of new blood vessels from pre-existing vessels, is one
rate-limiting factor that supports the development of adipose tissue during obesity.
