ABSTRACT
Bonito (Katsuobushi-Oligopeptide) ....................................................... 249 10.4 Isolation and Antihypertensive Activities of ACE-Inhibitory
Peptides from the Katsuobushi-Oligopeptide ........................................ 252 10.5 Classifi cation of ACE-Inhibitory Peptides by Preincubation
Method ................................................................................................... 253 10.6 Conclusion .............................................................................................. 256 References ......................................................................................................... 256
Bioactive peptides showing benefi cial effects on human health have been found in foods of marine origin. For example, anserine (β-alanyl 1-methyl-histidine) and carnosine (alanyl-histidine) found in bonito, tuna, and oyster show antioxidative
activity [1]. Bioactive peptides showing antihypertensive [2-16], antioxidative [17], α-glucosidase-inhibitory [18], and hypocholesterolemic activities [19], etc., also have been found in enzymatic digests of proteins from marine organisms. However, biological activities of these digests have been studied mostly in vitro, and a few of them have been studied in vivo, especially in humans. Among them, antihypertensive peptides based on the inhibition of angiotensin I-converting enzyme (ACE) have been studied most extensively. In this chapter, the antihypertensive functions of ACE-inhibitory peptides derived from marine organisms are described.
