ABSTRACT
The human genome contains approximately 25,000 genes,1 including an estimated 1,543 signaling receptors.2 Stimulation of these receptors can ultimately result in the activation or inhibition of transcription factors, of which there appear to be over 1,800 in humans,3 which direct the changes in cellular regulatory processes. Cellular signaling networks operate over diverse spatio-temporal scales, with various degrees of interconnectivity and a wide range of structural and dynamic dimensions that are just beginning to be mapped.4 Extensive efforts are being made to collect, collate, and extract knowledge from the abundant data being generated in this area, for example, the AfCS-Nature Signaling Gateway https://www.signaling-gateway.org, which includes both cell signaling databases and primary research results from around the world.
