ABSTRACT
Oligomer .........................................................................................340 17.8 Future Prospects ..........................................................................................344 References ............................................................................................................344
Molecular modelling is a robust methodology for creating and analyzing the structures of biological molecules and their complexes. On the one hand, it is an integral part of crystallographic and nuclear magnetic resonance (NMR) structure determination packages; on the other hand, the protein structures can be created from sequences using only in silico computational methods. The second approach is especially important now in the genomics era when genome sequencing projects are producing plenty of valuable data. Additionally, in the case of membrane proteins, experimental determination of protein structures and the structures of their complexes is extremely difficult (see Chapter 13 and Chapter 14 on NMR and crystallography, respectively).
