ABSTRACT
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Structural proteomics (often called structural genomics) is the systematic investigation of the three-dimensional structures of the protein products of genes. Because gene sequencing has become automated and inexpensive, our knowledge of predicted sequences of proteins far overshadows what we know of their three-dimensional structures and functions. Owing to the enormity of the challenge of determining structures of large numbers of proteins, the field of structural proteomics is driving the development of economic, high-throughput methodology. Although the major sites involved are large centers, much of the new technology they are developing is applicable to the general field of protein biochemistry.
