ABSTRACT
Biotransformation of N-2 ’-Deoxyribosyl Nucleosides .................................410 14.2.6 Immobilization of Whole Cells ....................................................................411
14.2.7 Synthesis of Different Nucleoside Analogs .................................................. 414
14.3 Conclusions .............................................................................................................. 420
References .......................................................................................................................... 420
Nucleosides are involved in many biochemical processes, notably the storage and transfer of
genetic information. As a consequence, nucleoside analogs have been used in the treatment of
anti-immunodeficiency syndrome (AIDS), and other viral infections, such as those caused by
herpes viruses, and influenza A and B viruses [1]. Most of the approved antiviral drugs,
such as 3’-azido-2’,3’-dideoxythymidine (AZT, 1) or 2’,3’-dideoxyinosine (ddI, 2), shown in Figure 14.1, are naturally occurring nucleoside analogs that act by interfering with the
synthesis of viral nucleic acids.
