ABSTRACT
Biocatalysis for Synthesis for Chiral Pharmaceutical Intermediates 105
4.19 Anti-Infective Drugs ................................................................................................141
4.19.1 Microbial Hydroxylation of Pleuromutilin or Mutilin ................................ 141
4.19.2 Enzymatic Preparation of (R)-1,3-Butanediol and
(R)-4-Chloro-3-Hydroxybutonoate .............................................................. 141
4.19.3 Enzymatic Synthesis of L-b-Hydroxyvaline ................................................. 142 4.20 a1-Adrenoreceptor Antagonist ................................................................................ 143
4.20.1 Enzymatic Esterification and Ammonolysis ................................................143
4.21 Endothelin Receptor Antagonist..............................................................................145
