ABSTRACT
The technique of solubility enhancem ent by complexation has been employed for several decades. Many articles dealing with the solubilization of drug molecules through complexation have been published since the last comprehensive review on the subject over 15 years ago (Repta 1981). The interest in physical and chemical properties of inclusion complexes has grown considerably mainly due to the increased applications of cyclodextrins (CDs), cyclic carbohydrates known to form complexes with hydrophobic drugs. The objective of this chapter is to discuss some theoretical and practical considerations in applying the complexation technique to the formulation of insoluble compounds.
