ABSTRACT
Mitochondrial Dysfunction and Apoptosis ...........................................102 5.3.1 Peroxynitrite Reactivity ..............................................................102 5.3.2 Peroxynitrite-Dependent and Independent Pathways
Involved in Tyrosine Nitration in Mitochondria ........................103 5.3.2.1 Peroxynitrite-Mediated Nitration of Tyrosines ...........103 5.3.2.2 Peroxidase, Peroxide, and Nitrite-Mediated
Nitration of Tyrosine ...................................................105 5.3.2.3 Fenton Chemistry and Tyrosine Nitration ...................106 5.3.2.4 ·NO Reaction with Tyrosyl Radicals Leads to
Tyrosine Nitration ........................................................106 5.3.2.5 Tyrosine Nitration Is a Radical Termination
Reaction That Evidences ·NO Formation ...................107 5.3.3 Peroxynitrite Reactions with Components of the Energy
Metabolism .................................................................................107 5.3.3.1 Electron Transport Chain Components and ATP
Synthase .......................................................................107 5.3.3.2 Intermembrane Components ........................................108 5.3.3.3 Matrix Components .....................................................109
5.3.4 Peroxynitrite Reactions with Components of the Apoptotic Machinery .................................................................109
