Nitric Oxide and Cell Signaling: Redox Regulation of Ras Superfamily GTPases

Exchange on Redox-Active GTPases in the Presence of O2 ................275 11.8 Superoxide Anion Radical Mediates Guanine Nucleotide

Exchange on NKCD-Containing GTPases ...........................................279 11.9 Hydroxyl Radical Mediates Guanine Nucleotide Exchange on

NKSD-Containing GTPases ..................................................................280 11.10 Structural and Mechanistic Basis for •NO2/O2•−- and OH•-Mediated

Guanine Nucleotide Exchange on Rab and Rho GTPases ...................281 11.11 Role and Fate of Free Radical-Mediated GNE of Redox-Active

GTPases .................................................................................................283 11.12 Redox Signaling and GEFs ...................................................................284 11.13 Concluding Remarks .............................................................................284